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University of Pennsylvania Analytical Associate 3 in Philadelphia, Pennsylvania

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

Posted Job Title

Analytical Associate 3

Job Profile Title

Resource Technologist B

Job Description Summary

The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with the great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases. The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania, has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the “go-to” organization for public and private partners, who want to participate in the gene therapy space. Currently, we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.Continuation of all GTP positions is contingent upon funding.

Job Description

Our Vector Core is a state-of-the-art facility which provides vector-related materials and services in support of basic and translational research worldwide, producing vectors in support of IND-enabling research, conduct GLP assays, oversee CMO's in vector production and is expanding to conduct state-of-the art process development.

Due to significant growth, the Vector Core is looking for a new, Analytical Associate 3, to support the characterization and/or release of vector products for research, IND-enabling studies and phase I/II human clinical trials.

As an Analytical Associate 3, you will emerge as a subject matter expert in molecular or cell based assays and you will be conducting quality control assays to determine the quality, quantity and potency of viral-based vectors, while following established protocols or standard operating procedures (may be conducted under GLP conditions). You will be documenting your activities on batch record forms or in a database for QA review. You will clean and sterilize lab equipment and performing routine equipment maintenance. You will also be making suggestions to leadership on updates or corrections that need to be made to any protocols or standard operating procedures.

You will work both independently and as part of a team to accomplish project goals within specified timelines. Successful candidates will have a familiarity with aseptic techniques, mammalian cell culture, and molecular or cell-based assays. The assays and techniques that are frequently used in genome titer determination, infectivity, biodistribution, in vivo potency assays, endotoxin, purity assays and rcAAV, Mammalian Cell/Tissue Culture, qPCR, ddPCR, cell based potency assays, RNA expression, viral clearance, titration, ELISA, western blots and gels.

Qualifications:

  • BS degree in chemistry, biology, or related disciplines with 3-5 years of experience required

  • Must have experience with Aseptic Techniques and mammalian cell culture

  • Experience with molecular and cell based assays a must

  • Must be meticulous, detail oriented, and analytical

  • Must be highly motivated, have excellent organizational, communication and interpersonal skills

  • Must be able to work independently and as part of a multi-disciplinary team

Job Location - City, State

Philadelphia, Pennsylvania

Department / School

Perelman School of Medicine

Pay Range

Affirmative Action Statement Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.

Special Requirements Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.

The University of Pennsylvania's special character is reflected in the diversity of the Penn community. We seek talented faculty and staff who will constitute a vibrant community that draws on the strength that comes with a substantive institutional commitment to diversity along dimensions of race, ethnicity, gender, sexual orientation, age, religion, disability, veteran status, interests, perspectives, and socioeconomic status. Grounded in equal opportunity, nondiscrimination, and affirmative action, Penn's robust commitment to diversity is fundamental to the University's mission of advancing knowledge, educating leaders for all sectors of society, and public service. The University of Pennsylvania prohibits unlawful discrimination based on race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.

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